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Lessons from precision medicine in rheumatology


 2020 Jan 22:1352458519884249. doi: 10.1177/1352458519884249. [Epub ahead of print]

Author Information

1 Colton Center for Autoimmunity, New York University School of Medicine, New York, NY, USA.

2 Rheumatology Unit, Department of Medicine, School of Medical Science, State University of Campinas, Campinas, Brazil.


Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are two common autoimmune rheumatic diseases that vary in severity, clinical presentation, and disease course between individuals. Molecular and genetic studies of both diseases have identified candidate genes and molecular pathways that are linked to various disease outcomes and treatment responses. Currently, patients can be grouped into molecular subsets in each disease, and these molecular categories should enable precision medicine approaches to be applied in rheumatic diseases. In this article, we will review key lessons learned about disease heterogeneity and molecular characterization in rheumatology, which we hope will lead to personalized therapeutic strategies.