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Anti-neutrophil Cytoplasmic Antibodies (ANCA) as Disease Activity Biomarkers in a "Personalized Medicine Approach" in ANCA-Associated Vasculitis

Author

Osman MS1, Tervaert JWC2. Curr Rheumatol Rep. 2019 Dec 26;21(12):76. doi: 10.1007/s11926-019-0872-3.

Author Information

1 Division of Rheumatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

2 Division of Rheumatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada. cohenter@ualberta.ca.

Abstract

PURPOSE OF REVIEW: 

ANCA-associated vasculitides (AAV) are a group of rare diseases characterized by blood vessel inflammation and the presence of circulating anti-neutrophil cytoplasmic antibodies recognizing proteinase-3 (PR3) (PR3-ANCA) or myeloperoxidase (MPO), MPO-ANCA.

RECENT FINDINGS: 

Historically, ANCAs have been used as biomarkers for disease associations and increases of ANCA levels as predictors of relapse in patients with AAV. In this review, we will summarize and highlight the most recent developments for using ANCA as predictive biomarkers and review some of the important disease-specific features in patients with AAV.