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A highlight from the LUPUS 2014 meeting: eight great ideas

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Buyon JP1, Cohen P2, Merrill JT3, Gilkeson G4, Kaplan M5, James J6, McCune WJ7, Bernatsky S8, Elkon K9. Lupus Sci Med. 2015 Jun 30;2(1):e000087. doi: 10.1136/lupus-2015-000087. eCollection 2015.


This review describes eight 'great ideas' regarding bench-to-bedside considerations in systemic lupus erythematosus (SLE) presented at the second international LUPUS meeting in Quebec, September 2014. The topics included: correcting the impaired clearance of apoptotic fragments; optimisation of clinical trial design: the PERFECT (Pre Evaluation Reducing Frighteningly Elevated Coverable Targets) study; lipidomics and metabolomics in SLE; importance of the inflammasome; identification and treatment of asymptomatic autoimmunity: prevention of SLE; combining low doses of hydroxychloroquine and quinacrine for long-term maintenance therapy of SLE; reducing emergency room visits and the critical relevance of the autoantigen.