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Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both?

Author

Silverman GJ1, Azzouz DF2, Alekseyenko AV3. Curr Opin Immunol. 2019 Oct 4;61:80-85. doi: 10.1016/j.coi.2019.08.007. [Epub ahead of print]

Author Information

1 Laboratory of B cell Immunobiology, Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA. Electronic address: Gregg.Silverman@nyumc.org.

2 Laboratory of B cell Immunobiology, Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA.

3 Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

Throughout our lives we are immersed in, and colonized by, immense and complex microbial communities. These microbiota serve as activators and early sparring partners for the progressive construction of the layers within our immune defenses and are essential to immune homeostasis. Yet, at times imbalances within the microbiota may contribute to metabolic and immune regulatory abnormalities that underlie the development of inflammatory and autoimmune diseases. Here, we review recent progress in investigations of the microbiome, with emphasis on the gut microbiota associated with systemic autoimmunity. In particular, these studies are beginning to illuminate aspects of the pathogenesis of Systemic Lupus Erythematosus, and may suggest that interconnections with specific disease-associated patterns of dysbiosis within gut communities are bidirectional and mutually reinforcing.