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A Novel System to Categorize the Symptoms of Systemic Lupus Erythematosus

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Pisetsky DS1,2, Clowse MEB1, Criscione-Schreiber LG1, Rogers JL1. Arthritis Care Res (Hoboken). 2018 Oct 24. doi: 10.1002/acr.23794. [Epub ahead of print]


Author information 1 Department of Medicine, Division of Rheumatology and Immunology, Duke University Medical Center, Durham, North Carolina. 2 Medical Research Service, Durham Veterans Affairs Medical Center, Durham, North Carolina.

Abstract Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that varies markedly in severity and can be difficult to both diagnose and treat (1, 2). Many manifestations of SLE result from well-defined immune mechanisms that drive systemic as well as local inflammation. If not adequately controlled, these manifestations can lead to organ injury and dysfunction (3). Other manifestations of SLE are vague in origin and have an uncertain relationship to inflammation.