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Beyond Arthritis: Understanding the Influence of Gout on Erectile Function: A Systematic Review

Author

Urology. 2020 Dec 17;S0090-4295(20)31492-8. doi: 10.1016/j.urology.2020.12.005.Online ahead of print.

Kyle Park 1Nikhil K Gupta 2Ephrem O Olweny 2Naomi Schlesinger 3

Author Information

1 Division of Rheumatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. Electronic address: parky4@rwjms.rutgers.edu.

2 Division of Urology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

3 Division of Rheumatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Abstract

Objective: To review the evidence suggesting a significant association between gout and erectile dysfunction (ED) and evaluate possible underlying pathways that may explain this relationship.

Methods: English medical literature was searched from January 1, 2010, to January 1, 2020, for randomized or quasi-randomized controlled trials, cross-sectional studies, case-cohort studies, or meta-analysis evaluating the relationship between gout and ED.

Results: All nine gout studies included in the study found a significant association between gout and ED. ED pathophysiology in gout involves hyperuricemia, increased reactive oxygen species, decreased nitric oxide synthesis, and low-grade inflammation.

Conclusion: The findings of this review suggest that the effect of urate-lowering therapy on the incidence of ED in gout patients should be studied. Additionally, we propose that all gout patients should be assessed for ED.