Abstract Library

The summaries are free for public use. ARTHROS will continue to add and archive summaries of articles deemed relevant to ARTHROS by our Faculty.

1

Simulation-based design of pragmatic trials in psoriatic arthritis using propensity scores

Clin Trials. 2021 Aug 25;17407745211023840. doi: 10.1177/17407745211023840.Online ahead of print.

Sarah M Weinstein 1Laura C Coates 2Philip S Helliwell 3Alexis Ogdie 1 4Alisa J Stephens-Shields 1

2

Descriptive Comparisons of the Effect of Apremilast and Methotrexate Monotherapy in Oligoarticular Psoriatic Arthritis: The Corrona Psoriatic Arthritis/Spondyloarthritis Registry Results

J Rheumatol. 2021 May;48(5):693-697. doi: 10.3899/jrheum.191209. Epub 2020 Nov 15.

Alexis Ogdie 1Mei Liu 2Meghan Glynn 2Kelechi Emeanuru 2Leslie R Harrold 3Sven Richter 4Benoit Guerette 4Philip J Mease 5

3

Risk of Osteoarthritis in an Incident Cohort of People With Psoriatic Arthritis: A Population-based Cohort Study

J Rheumatol. 2021 Jun;48(6):841-846. doi: 10.3899/jrheum.200564. Epub 2020 Nov 15.

Rachel A Charlton 1Amelia Green 1Gavin Shaddick 2Julia Snowball 1Alison Nightingale 1William Tillett 3Catherine Smith 4Neil J McHughPROMPT Study Group

4

Healthcare Cost and Utilization Associated with Biologic Treatment Patterns Among Patients with Psoriatic Arthritis: Analyses from a Large US Claims Database

Drugs Real World Outcomes. 2021 Mar;8(1):29-38. doi: 10.1007/s40801-020-00217-4.Epub 2020 Nov 12.

Peter Hur 1Nina Kim 2 3Dong Dai 4Olivia W Piao 5Josh Z Zheng 5Esther Yi 4

5

Does age matter in Psoriatic arthritis? A narrative review

J Rheumatol. 2021 Aug 15;jrheum.210349. doi: 10.3899/jrheum.210349. Online ahead of print.

George E Fragoulis 1Elena Nikiphorou 1Iain B McInnes 1Stefan Siebert 1

6

Are fatty acids associated with disease activity and biomarkers in patients with psoriatic arthritis? Data from a multicenter clinical trial

Rheumatol Int. 2021 Jul 29. doi: 10.1007/s00296-021-04953-w. Online ahead of print.

Salome Kristensen 1 2Signe Holm Nielsen 3 4Erik Berg Schmidt 5 6Anne Christine Bay-Jensen 3Morten A Karsdal 3Jeppe Hagstrup Christensen 5 7

7

Evaluation of Improvement in Skin and Nail Psoriasis in Bio-naïve Patients With Active Psoriatic Arthritis Treated With Golimumab: Results Through Week 52 of the GO-VIBRANT Study

ACR Open Rheumatol. 2020 Nov;2(11):640-647. doi: 10.1002/acr2.11180. Epub 2020 Oct 19.

Philip Mease 1M Elaine Husni 2Soumya D Chakravarty 3Shelly Kafka 4Dennis Parenti 4Lilianne Kim 5Kim Hung Lo 5Elizabeth C Hsia 6Arthur Kavanaugh 7

8

Brodalumab in psoriatic arthritis: results from the randomised phase III AMVISION-1 and AMVISION-2 trials

Ann Rheum Dis. 2021 Feb;80(2):185-193.doi: 10.1136/annrheumdis-2019-216835. Epub 2020 Oct 26.

Philip J Mease 1Philip S Helliwell 2Kasper Fjellhaugen Hjuler 3Kyle Raymond 4Iain McInnes 5

9

Psoriatic arthritis is associated with adverse body composition predictive of greater coronary heart disease and type 2 diabetes propensity - a cross-sectional study

Rheumatology (Oxford). 2021 Apr 6;60(4):1858-1862. doi: 10.1093/rheumatology/keaa604.

Lyn D Ferguson 1Jennifer Linge 2 3Olof Dahlqvist Leinhard 2 3Rosemary Woodward 4Pauline Hall Barrientos 4Giles Roditi 4Aleksandra Radjenovic 1Iain B McInnes 5Stefan Siebert 5Naveed Sattar 1

10

Secukinumab provides sustained improvement in signs and symptoms and low radiographic progression in patients with psoriatic arthritis: 2-year (end-of-study) results from the FUTURE 5 study

RMD Open. 2021 Jul;7(2):e001600. doi: 10.1136/rmdopen-2021-001600.

Philip J Mease 1Robert Landewé 2 3Proton Rahman 4Hasan Tahir 5Atul Singhal 6Elke Boettcher 7Sandra Navarra 8Aimee Readie 9Shephard Mpofu 10Eumorphia Maria Delicha 10Luminita Pricop 9Desirée van der Heijde 11

11

Network Meta-Analysis of Tofacitinib, Biologic Disease-Modifying Antirheumatic Drugs, and Apremilast for the Treatment of Psoriatic Arthritis

Curr Ther Res Clin Exp. 2020 Aug 12;93:100601. doi: 10.1016/j.curtheres.2020.100601.eCollection 2020.

Dafna D Gladman 1Ana-Maria Orbai 2Juan Gomez-Reino 3Stacey Chang-Douglass 4Emanuele Leoncini 4Hannah E Burton 4Keith S Kanik 5Ana Belen Romero 6Joseph C Cappelleri 5Ming-Ann Hsu 5

12

Multimorbidity and comorbidity in psoriatic arthritis - a perspective

Expert Rev Clin Immunol. 2020 Oct;16(10):963-972 doi:10.1080/1744666X.2021.1825941.Epub 2020 Oct 3.

Ennio Lubrano 1Silvia Scriffignano 1Fabio Massimo Perrotta 1

13

Linking the patient experience of foot involvement related to psoriatic arthritis to the International Classification of Functioning, Disability and Health

Rheumatol Adv Pract. 2020 Jul 11;4(2):rkaa028. doi: 10.1093/rap/rkaa028. eCollection 2020.

Kate Carter 1Caterina Tannous 2Steven Walmsley 1Keith Rome 3Deborah E Turner 1 4

14

Tofacitinib in Patients With Psoriatic Arthritis and Metabolic Syndrome: A Post hoc Analysis of Phase 3 Studies

ACR Open Rheumatol. 2020 Oct;2(10):543-554. doi: 10.1002/acr2.11166. Epub 2020 Sep 10.

Christopher T Ritchlin 1Jon T Giles 2Alexis Ogdie 3Juan J Gomez-Reino 4Philip Helliwell 5Pamela Young 6Cunshan Wang 7Joseph Wu 7Ana Belén Romero 8John Woolcott 6Lori Stockert 6

15

Histological Evaluation of the Relationships Between Distal Interphalangeal Psoriatic Arthritis and Nail Psoriasis: Correlations With Anatomical Studies of the Normal Nail Unit and the Main Radiological Data Concerning Distal Interphalangeal Psoriatic Arthritis

Am J Dermatopathol. 2020 Dec;42(12):911-915. doi: 10.1097/DAD.0000000000001786.

Christophe Perrin 1 2

16

Performance of composite measures used in a trial of etanercept and methotrexate as monotherapy or in combination in psoriatic arthritis

Rheumatology (Oxford). 2021 Mar 2;60(3):1137-1147. doi: 10.1093/rheumatology/keaa271.

Laura C Coates 1Joseph F Merola 2Philip J Mease 3Alexis Ogdie 4Dafna D Gladman 5Vibeke Strand 6Leonieke J J van Mens 7Lyrica Liu 8Priscilla K Yen 9David H Collier 10Gregory Kricorian 10James B Chung 10Philip S Helliwell 11

17

Barriers to shared decision-making with women of reproductive age affected by a chronic inflammatory disease: a mixed-methods needs assessment of dermatologists and rheumatologists

BMJ Open. 2021 Jun 16;11(6):e043960. doi: 10.1136/bmjopen-2020-043960.

Suzanne Murray 1Monica Augustyniak 2Jenny E Murase 3 4Rebecca Fischer-Betz 5Catherine Nelson-Piercy 6Morgan Peniuta 2Ivo Vlaev 7

18

Predictive factors for switching in patients with psoriatic arthritis undergoing anti-TNFa, anti-IL12/23, or anti-IL17 drugs: a 15-year monocentric real-life study

Clin Rheumatol. 2021 Jun 16. doi: 10.1007/s10067-021-05799-0. Online ahead of print.

Mariagrazia Lorenzin # 1Augusta Ortolan # 1Giacomo Cozzi 1Antonia Calligaro 1Maria Favaro 1Teresa Del Ross 1Andrea Doria 1Roberta Ramonda 2

19

Measurement of minimal disease activity in psoriatic arthritis using PROMIS-Physical Function or the Health Assessment Questionnaire-Disability Index

Arthritis Care Res (Hoboken). 2020 Aug 29;10.1002/acr.24433. doi: 10.1002/acr.24433.Online ahead of print.

Erin Chew 1 2Jamie Perin 3Thomas Grader-Beck 1Ana-Maria Orbai 1

20

Psoriatic arthritis: exploring the occurrence of sleep disturbances, fatigue, and depression and their correlates

Arthritis Res Ther. 2020 Aug 26;22(1):198. doi: 10.1186/s13075-020-02294-w.

Glenn Haugeberg 1 2Mari Hoff 3Arthur Kavanaugh 4Brigitte Michelsen 5

21

Effectiveness and treatment retention of TNF inhibitors when used as monotherapy versus comedication with csDMARDs in 15 332 patients with psoriatic arthritis. Data from the EuroSpA collaboration

Ann Rheum Dis. 2021 Jun 3;annrheumdis-2021-220097.doi: 10.1136/annrheumdis-2021-220097. Online ahead of print.

Ulf Lindström 1Daniela Di Giuseppe 2Bénédicte Delcoigne 2Bente Glintborg 3 4Burkhard Möller 5Adrian Ciurea 6Manuel Pombo-Suarez 7Carlos Sanchez-Piedra 8Kari Eklund 9 10Heikki Relas 9Bjorn Gudbjornsson 11 12Thorvardur Jon Love 12 13Gareth T Jones 14Catalin Codreanu 15Ruxandra Ionescu 16Lucie Nekvindova 17 18Jakub Závada 19 20Nuh Atas 21Servet Yolbas 22Karen Minde Fagerli 23Brigitte Michelsen 23 24Žiga Rotar 25 26Matija Tomšic 25 26Florenzo Iannone 27Maria Jose Santos 28Pedro Avila-Ribeiro 29 30Lykke Midtbøll Ørnbjerg 31Mikkel Østergaard 31 32Lennart Th Jacobsson 33Johan Askling 2Michael J Nissen 34

22

Systematic review and meta-analysis on prevalence of metabolic syndrome in psoriatic arthritis, rheumatoid arthritis and psoriasis

Int J Rheum Dis. 2021 Jun 2. doi: 10.1111/1756-185X.14147. Online ahead of print.

Aravinthan Loganathan 1 2 3Narainraj Kamalaraj 1 4Carlos El-Haddad 1Kevin Pile 1 3

23

GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting

J Rheumatol Suppl. 2021 Jun;97:65-66. doi: 10.3899/jrheum.201681.

Laura C Coates 1Nadia Corp 2Danielle A van der Windt 2Enrique R Soriano 3Arthur Kavanaugh 4

24

GRAPPA Patient Research Partner Network: Update to the GRAPPA 2020 Annual Meeting

J Rheumatol Suppl. 2021 Jun;97:64. doi: 10.3899/jrheum.201680.

Denis P O'Sullivan 1Ingrid Steinkoenig 2

25

Development of a national survey on foot involvement among people with psoriatic arthritis in Australia using a best practice approach: a survey development protocol

J Foot Ankle Res. 2020 Aug 26;13(1):53. doi: 10.1186/s13047-020-00424-w.

Kate Carter 1Steven Walmsley 2Keith Rome 3Deborah E Turner 4

26

Development and Validation of a Sonographic Enthesitis Instrument in Psoriatic Arthritis: The GRAPPA Diagnostic Ultrasound Enthesitis Tool (DUET) Project

J Rheumatol Suppl. 2020 Jun;96:50-52. doi: 10.3899/jrheum.200128.

Lihi Eder 1 2Gurjit S Kaeley 3 4Sibel Zehra Aydin 3 4

27

JAK inhibitors, Psoriatic Arthritis, and Axial Spondyloarthritis: a Critical Review of Clinical Trials

Expert Rev Clin Immunol. 2021 May 4. doi: 10.1080/1744666X.2021.1925541.Online ahead of print.

Stephanie Keeling 1Walter P Maksymowych 1

28

Updated therapies for the management of Psoriatic Arthritis

Clin Immunol. 2020 Nov;220:108536. doi: 10.1016/j.clim.2020.108536.Epub 2020 Jul 16.

Atrin Toussi 1Natalia Maverakis 2Stephanie T Le 3Soumajyoti Sarkar 4Smriti K Raychaudhuri 5Siba P Raychaudhuri 6

29

Test-retest reliability for HAQ-DI and SF-36 PF for the measurement of physical function in psoriatic arthritis

J Rheumatol. 2021 Apr 15;jrheum.210175. doi: 10.3899/jrheum.210175. Online ahead of print.

Ying Ying Leung 1William Tillett 1Pil Hojgaard 1Ana-Maria Orbai 1Richard Holland 1Ashish J Mathew 1Niti Goel 1Jeffrey Chau 1Chris Lindsay 1Alexis Ogdie 1Laura C Coates 1Robin Christensen 1Philip Mease 1Vibeke Strand 1Dafna D Gladman 1

30

Pregnancy in women with psoriatic arthritis: A systematic literature review of disease activity and adverse pregnancy outcomes

Semin Arthritis Rheum. 2021 Apr 15;51(3):530-538.doi: 10.1016/j.semarthrit.2021.04.003. Online ahead of print.

Yvette Meissner 1Tatjana Rudi 2Rebecca Fischer-Betz 3Anja Strangfeld 2

31

The risk of malignancy in secukinumab-treated psoriasis, psoriatic arthritis and ankylosing spondylitis patients: analysis of up to five-year clinical trial and post-marketing surveillance data

Br J Dermatol. 2021 Apr 8. doi: 10.1111/bjd.20136. Online ahead of print.

M Lebwohl 1A Deodhar 2C E M Griffiths 3M A Menter 4D Poddubnyy 5W Bao 6V Jehl 7K Marfo 7P Primatesta 7A Shete 7V Trivedi 6P J Mease 8

32

GRAPPA Treatment Recommendations: Updates and Methods

J Rheumatol Suppl. 2020 Jun;96:41-45. doi: 10.3899/jrheum.200126.

Arthur Kavanaugh 1 2Laura C Coates 3 4Danielle A van der Windt 3 4Nadia Corp 3 4Enrique R Soriano 3 4

33

Safety and Efficacy of Tofacitinib in Patients with Active Psoriatic Arthritis: Interim Analysis of OPAL Balance, an Open-Label, Long-Term Extension Study

Rheumatol Ther. 2020 Sep;7(3):553-580.doi: 10.1007/s40744-020-00209-4. Epub 2020 Jun 6.

Peter Nash 1Laura C Coates 2Alan J Kivitz 3Philip J Mease 4Dafna D Gladman 5José A Covarrubias-Cobos 6Oliver FitzGerald 7Dona Fleishaker 8Cunshan Wang 8Joseph Wu 8Ming-Ann Hsu 8Sujatha Menon 8Lara Fallon 9Ana Belén Romero 10Keith S Kanik 8

34

Methotrexate in Psoriasis and Psoriatic Arthritis

J Rheumatol Suppl. 2020 Jun;96:31-35. doi: 10.3899/jrheum.200124.

Laura C Coates 1 2 3Joseph F Merola 4 5 6Suzanne M Grieb 4 5 6Philip J Mease 4 5 6Kristina Callis Duffin 4 5 6

35

Resolution of Enthesitis by Guselkumab and Relationships to Disease Burden: 1-Year Results of Two Phase-3 Psoriatic Arthritis Studies

Rheumatology (Oxford). 2021 Apr 6;keab285. doi: 10.1093/rheumatology/keab285.Online ahead of print.

Dennis McGonagle 1Iain B McInnes 2Atul Deodhar 3Georg Schett 4May Shawi 5Shelly Kafka 6Chetan S Karyekar 5Alexa P Kollmeier 7Elizabeth C Hsia 7 8Xie L Xu 7Shihong Sheng 9Prasheen Agarwal 9Bei Zhou 9Christopher T Ritchlin 10Proton Rahman 11Philip J Mease 12

36

Current treatments and recommendations

Best Pract Res Clin Rheumatol. 2021 Apr 3;101680. doi: 10.1016/j.berh.2021.101680.Online ahead of print.

Arani Vivekanantham 1Dylan McGagh 2Laura C Coates 3

37

Disease Characteristics, Quality of Life, and Work Productivity by Enthesitis Site: Real-world Data From the US Corrona Psoriatic Arthritis/Spondyloarthritis Registry

J Rheumatol. 2020 Jun 1;jrheum.191117. doi: 10.3899/jrheum.191117. Online ahead of print.

Philip J Mease 1Mei Liu 1Sabrina Rebello 1Winnie Hua 1Robert R McLean 1Peter Hur 1Alexis Ogdie 1

38

Psoriatic arthritis and COVID-19 pandemic: Consequences in medical treatment?

Dermatol Ther. 2020 Sep;33(5):e13743. doi: 10.1111/dth.13743. Epub 2020 Jun 30.

Uwe Wollina 1Massimo Fioranelli 2Mohamad Goldust 3 4 5Torello Lotti 6

39

Not your average joint: Towards precision medicine in psoriatic arthritis

Clin Immunol. 2020 Aug;217:108470. doi: 10.1016/j.clim.2020.108470.Epub 2020 May 28.

Rochelle Castillo 1Jose U Scher 2

40

Evaluation of a Genetic Risk Score for Diagnosis of Psoriatic Arthritis

J Psoriasis Psoriatic Arthritis. 2020 Apr;5(2):61-67. doi: 10.1177/2475530320910814.Epub 2020 Mar 4.

Mary Patricia Smith 1Karen Ly 1Quinn Thibodeaux 1Kristen Beck 1Eric Yang 1 2Isabelle Sanchez 1 3Joanne Nititham 1Tina Bhutani 1Wilson Liao 1

41

Risk for development of inflammatory bowel disease under inhibition of interleukin 17: A systematic review and meta-analysis

PLoS One. 2020 May 27;15(5):e0233781. doi: 10.1371/journal.pone.0233781.eCollection 2020.

Johan Burisch 1Wolfgang Eigner 2Stefan Schreiber 3Daniel Aletaha 4Wolfgang Weninger 5Michael Trauner 2Walter Reinisch 2Neeraj Narula 6

42

Costs and Health Outcomes Associated with Tofacitinib Treatment for Active Psoriatic Arthritis in the United States

J Manag Care Spec Pharm. 2020 Aug;26(8):1027-1038. doi: 10.18553/jmcp.2020.19319.Epub 2020 Apr 20.

George Bungey 1Stacey Chang-Douglass 1Ming-Ann Hsu 2Joseph C Cappelleri 2Pamela Young 3John Woolcott 3

43

Real-world 2-year treatment patterns among patients with psoriatic arthritis treated with injectable biologic therapies

Curr Med Res Opin. 2020 Jul;36(7):1245-1252. doi: 10.1080/03007995.2020.1754186.Epub 2020 Apr 23.

Jessica A Walsh 1Qian Cai 2Iris Lin 3Timothy Fitzgerald 3Christopher D Pericone 2Soumya D Chakravarty 3 4

44

Tumor Necrosis Factor Inhibitor Monotherapy Versus Combination Therapy for the Treatment of Psoriatic Arthritis: Combined Analysis of European Biologics Databases

J Rheumatol. 2021 Jan 1;48(1):48-57. doi: 10.3899/jrheum.190815. Epub 2020 Apr 1.

Matthew L Thomas 1Gavin Shaddick 2Rachel Charlton 3Charlotte Cavill 4Richard Holland 4Florenzo Iannone 5Giovanni Lapadula 5Simona Lopriore 5Jakub Závada 6Michal Uher 7Karel Pavelka 6Lenka Szczuková 7Prodromos Sidiropoulos 8Irini Flouri 8Alexandros Drosos 9Burkhard Möller 10Michael J Nissen 11Rüdiger B Müller 12Almut Scherer 13Neil McHugh 14Alison Nightingale 15

45

Psoriatic arthritis in childhood: A commentary on the controversy

Clin Immunol. 2020 May;214:108396. doi: 10.1016/j.clim.2020.108396.Epub 2020 Mar 27.

Matthew L Stoll 1Elizabeth D Mellins 2

46

Challenges in the clinical diagnosis of psoriatic arthritis

Clin Immunol. 2020 May;214:108390. doi: 10.1016/j.clim.2020.108390.Epub 2020 Mar 18.

Mohamad Ali Rida 1Vinod Chandran 2

47

Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial

Lancet. 2020 Apr 4;395(10230):1126-1136.doi: 10.1016/S0140-6736(20)30263-4. Epub 2020 Mar 13.

Philip J Mease 1Proton Rahman 2Alice B Gottlieb 3Alexa P Kollmeier 4Elizabeth C Hsia 5Xie L Xu 4Shihong Sheng 6Prasheen Agarwal 6Bei Zhou 6Yanli Zhuang 7Désirée van der Heijde 8Iain B McInnes 9DISCOVER-2 Study Group

48

Complexities in Genetics of Psoriatic Arthritis

Curr Rheumatol Rep. 2020 Mar 12;22(4):10. doi: 10.1007/s11926-020-0886-x.

Sara Rahmati 1 2Lam Tsoi 3Darren O'Rielly 1Vinod Chandran 1 2 4 5 6Proton Rahman 7

49

Prevalence of extra-articular manifestations in psoriatic arthritis: a systematic review and meta-analysis

Rheumatology (Oxford). 2020 Sep 1;59(9):2199-2206.doi: 10.1093/rheumatology/keaa062.

Bradley Pittam 1Sonal Gupta 1Nicholas L Harrison 2Selina Robertson 1David M Hughes 3Sizheng Steven Zhao 2 4

50

The many faces of psoriatic arthritis: their genetic determinism

Rheumatology (Oxford). 2020 Mar 1;59(Suppl 1):i4-i9.doi: 10.1093/rheumatology/kez325.

Robert Winchester 1Oliver FitzGerald 2

51

Ixekizumab for the treatment of psoriasis: up-to-date

Expert Opin Biol Ther. 2020 Jun;20(6):549-557.doi: 10.1080/14712598.2020.1729736. Epub 2020 Mar 10.

Sarah Craig 1 2Richard B Warren 3

52

Drug interactions in the treatment of rheumatoid arthritis and psoriatic arthritis

Rheumatol Int. 2020 Apr;40(4):511-521. doi: 10.1007/s00296-020-04526-3.Epub 2020 Feb 12.

Stephan Pflugbeil 1Karin Böckl 2Reinhold Pongratz 1Marianne Leitner 3Winfried Graninger 4Astrid Ortner 5

53

Inhibition of radiographic progression across levels of composite index-defined disease activity in patients with active psoriatic arthritis treated with intravenous golimumab: results from a phase-3, double-blind, placebo-controlled trial

Arthritis Res Ther. 2020 Mar 6;22(1):43. doi: 10.1186/s13075-020-2126-1.

Philip Mease 1, M Elaine Husni 2, Shelly Kafka 3, Soumya D Chakravarty 3 4, Diane D Harrison 5, Kim Hung Lo 5, Stephen Xu 5, Elizabeth C Hsia 5 6, Arthur Kavanaugh 7

54

Identifying and Characterizing Psoriasis and Psoriatic Arthritis Patients in Ontario Administrative Data: A Population-based Study From 1991 to 2015

J Rheumatol. 2020 Nov 1;47(11):1644-1651. doi: 10.3899/jrheum.190659. Epub 2020 Feb 15.

Lihi Eder 1, Jessica Widdifield 2, Cheryl F Rosen 3, Raed Alhusayen 4, Stephanie Y Cheng 5, Jacqueline Young 5, Willemina Campbell 6, Sasha Bernatsky 7, Dafna D Gladman 8, Michael Paterson 9, Karen Tu 10

55

Remission in psoriatic arthritis: Definition and predictors

Semin Arthritis Rheum. 2020 Dec;50(6):1494-1499. doi: 10.1016/j.semarthrit.2020.01.012.Epub 2020 Feb 3.

Samar Alharbi 1, Justine Y Ye 2, Ker-Ai Lee 3, Vinod Chandran 4, Richard J Cook 3, Dafna D Gladman 5