abstract details

The summaries are free for public use. ARTHROS will continue to add and archive summaries of articles deemed relevant to ARTHROS by our Faculty.

Systematic review and network meta-analysis: effect of biologics on radiographic progression in rheumatoid arthritis

Author information

Murray E1, Ellis A1, Butylkova Y1, Skup M2, Kalabic J3, Garg V2. J Comp Eff Res. 2018 Aug 21. doi: 10.2217/cer-2017-0106. [Epub ahead of print]

Abstract

Author information

1 Doctor Evidence, Santa Monica, CA, 90401, USA.

2 AbbVie, North Chicago, IL, 60064, USA.

3 AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany.

Abstract

AIM: To evaluate the comparative effectiveness of biologics in inhibiting radiographic progression among rheumatoid arthritis(RA) patients.

MATERIALS & METHODS: Bayesian network meta-analysis of published trials investigating the USA FDA approved biologics treatment in RA patients, using methotrexate (MTX) as the reference comparator.

RESULTS: Nine trials met the inclusion criteria for base case analysis. Compared with MTX, most biologics (except golimumab) + MTX had significantly lower rates of radiographic progression at 1 year. Mean difference in radiographic progression rates between MTX monotherapy and biologics + MTX was highest for adalimumab + MTX (-3.8) and lowest for tocilizumab + MTX (-0.7). Inhibition of radiographic progression was sustained.

CONCLUSION: Biologics inhibit radiographic progression in patients with RA at 1 year; however, published evidence beyond 1 year is limited.