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Nonradiographic axial spondyloarthritis: clinical and therapeutic relevance

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Ghosh N1, Ruderman EM2. Arthritis Res Ther. 2017 Dec 22;19(1):286. doi: 10.1186/s13075-017-1493-8.

Abstract

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1 Northwestern University Feinberg School of Medicine, 675 North St. Clair, Suite 14-100, Chicago, IL, 60611, USA.

2 Northwestern University Feinberg School of Medicine, 675 North St. Clair, Suite 14-100, Chicago, IL, 60611, USA. e-ruderman@northwestern.edu.

Abstract

Current classification criteria for axial spondyloarthritis (axSpA) provide for the inclusion of patients with a wide range of presentations and manifestations. While not considered a formal subclassification, patients are often divided into radiographic or nonradiographic axSpA based on the presence or absence of radiographic sacroiliitis. This review will focus on nonradiographic axSpA and will discuss clinical manifestations of disease that distinguish, or in many cases do not distinguish, this entity from other individuals with axSpA. This review will also cover treatment paradigms for nonradiographic axSpA, particularly the use of biologic therapies, where current data suggest that nonradiographic disease should be managed largely the same as radiographic disease, or classical ankylosing spondylitis.